P134 Sensitisation To Cross-reactive Carbohydrate Determinants In Britain's Bakers: The Implications For Health Surveillance
نویسندگان
چکیده
منابع مشابه
Coping with cross-reactive carbohydrate determinants in allergy diagnosis
A relevant proportion of allergy diagnosis is accomplished by in vitro determination of specific immunglobulin E (sIgE) to extracts from suspected allergens. Such extracts inevitably contain glycoproteins, which may react with patients' IgE. In the case of plant and insect allergens, the relevant epitope structure is an α-1,3-fucose on the Asn-linked sugar residue of so-called N-glycans. Due to...
متن کاملReduction of Cross-Reactive Carbohydrate Determinants in Plant Foodstuff: Elucidation of Clinical Relevance and Implications for Allergy Diagnosis
BACKGROUND A longstanding debate in allergy is whether or not specific immunoglobulin-E antibodies (sIgE), recognizing cross-reactive carbohydrate determinants (CCD), are able to elicit clinical symptoms. In pollen and food allergy, ≥20% of patients display in-vitro CCD reactivity based on presence of α1,3-fucose and/or β1,2-xylose residues on N-glycans of plant (xylose/fucose) and insect (fuco...
متن کاملInhibition of IgE binding to cross-reactive carbohydrate determinants enhances diagnostic selectivity
BACKGROUND Allergy diagnosis by determination of allergen-specific IgE is complicated by clinically irrelevant IgE, of which the most prominent example is IgE against cross-reactive carbohydrate determinants (CCDs) that occur on allergens from plants and insects. Therefore, CCDs cause numerous false-positive results. Inhibition of CCDs has been proposed as a remedy, but has not yet found its wa...
متن کاملWheat flour sensitisation and airways disease in urban bakers.
A total of 176 bakers and 24 subjects employed as bread slicers and wrappers were studied to examine the effect of occupational category on respiratory symptoms, ventilatory capacity, non-specific bronchial reactivity, and prick skin test responses to wheat and common allergens. Bakers had a greater prevalence of attacks of wheeze and dyspnoea and more frequently considered that work affected t...
متن کاملIdentification of cross-reactive carbohydrate determinants in subjects reporting work-related respiratory symptoms.
INTRODUCTION The role of cross-reactive carbohydrate determinants (CCDs) in diagnostics of occupational allergy remains unclarified and its clinical relevance is still questioned. The aim of the study was to assess the frequency of positive response to CCDs in the subjects with suspected occupational allergy and the relationship between other diagnostic test results and final diagnosis. MATER...
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ژورنال
عنوان ژورنال: Thorax
سال: 2014
ISSN: 0040-6376
DOI: 10.1136/thoraxjnl-2014-206260.275